Spravato® (esketamine) is an FDA-approved nasal medication used in conjunction with an oral antidepressant for treatment-resistant depression and major depressive disorder with acute suicidal ideation. It works through the NMDA receptor to restore synaptic connections and improve mood.

All sessions take place in-clinic under medical supervision and require a minimum 2-hour observation period following each dose to ensure your safety.

24 Hours Before Your Appointment

  • Arrange transportation: You will not be permitted to drive or operate machinery for the rest of the day after treatment. Arrange a trusted ride to and from the clinic.
  • Avoid alcohol and recreational drugs for at least 24 hours prior.
  • Eat a light meal no later than 2 hours before your session and avoid heavy or greasy foods that may worsen nausea.
  • Limit caffeine intake on the day of treatment.
  • Take routine medications as prescribed unless your clinician instructs otherwise.
  • Notify your provider if you’ve had changes in medical status (illness, infection, blood pressure changes, new medications, or substance use).

Day of Treatment

  • Dress comfortably and bring a light blanket or sweater if desired.
  • Avoid wearing fragrances or lotions near the nose, as they can irritate the nasal passage.
  • Use the restroom before dosing; you’ll need to remain seated for most of the observation period.
  • A clinician will measure your blood pressure and heart rate before administration and periodically throughout the session.
  • You’ll self-administer Spravato® nasal sprays under direct supervision.
  • The session typically lasts about 2 hours, including observation.
  • Common short-term effects include: mild dissociation, drowsiness, dizziness, blurred vision, or feeling “floaty.” These resolve as the medication wears off.
  • Staff will monitor you continuously to ensure your comfort and safety.

Immediately After

  • Do not drive, operate machinery, or make important decisions for the remainder of the day.
  • Expect mild fatigue or lightheadedness for several hours; rest is encouraged.
  • Have a ride home and someone check in if you live alone.
  • Hydrate well and eat a light meal once you feel ready.

First 24 Hours

  • Avoid alcohol, recreational drugs, and sedating medications not cleared by your provider.
  • Resume normal activities the next day unless you feel persisting drowsiness or imbalance.
  • Continue your oral antidepressant and any other prescribed medications as directed.
  • Contact your clinic if you experience severe headache, confusion, prolonged nausea, or unusual mood changes.
  • Initial series: Spravato® is typically administered twice weekly for the first 4 weeks, then weekly to bi-weekly for maintenance.
  • Most patients notice mood improvement within 2–6 sessions.
  • Regular check-ins with your prescriber help track response and adjust your treatment plan.
  • Consistent sleep, hydration, balanced nutrition, and therapy complement optimal results.

WHEN TO CONTACT US IMMEDIATELY

  • Thoughts of self-harm or worsening depression
  • Severe nausea, vomiting, or persistent dizziness
  • Chest pain, shortness of breath, or rapid heartbeat

If emergent symptoms occur after hours, call 911 or go to the nearest emergency department.

If you have any questions or concerns, please contact:
📞 (617) 668-1239
✉️ support@aestheticmindmd.com

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Contact Us

support@aestheticmindmd.com
(617) 668-1239

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